Image Registration for Microwave Tomography of the Breast Using Priors from Non-Simultaneous Previous Magnetic Resonance Imaging
Gregory Boverman, Cynthia Davis, Shireen Geimer
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For the neoadjuvant therapy application, it would be desirable to achieve the most accurate possible characterization of the tissue properties. One method to achieve increased resolution and specificity in microwave imaging reconstruction is the use of a soft prior regularization. The objective of this study is to develop a method to use magnetic resonance (MR) images, taken in a different imaging configuration, as this soft prior. To enable the use of the MR images as a soft prior, it is necessary to register the MR images to the microwave imaging space. Registration fiducials were placed around the breast that are visible in both the MRI and with an optical scanner integrated into the microwave system. Utilizing these common registration locations, numerical algorithms have been developed to warp the original breast MR images into a geometry closely resembling that in which the breast is pendant in the microwave system.
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- To achieve increased resolution and specificity in microwave imaging reconstruction a soft prior regularization can be used from pre-microwave imaging MRI performed as part of standard clinical care for breast cancer.
- The targeted application is breast cancer imaging for neoadjuvant chemotherapy monitoring.
- Utilizing a limited set of skin fiducial markers numerical algorithms have been developed to warp the original breast MR images into a geometry closely resembling that for when the breast is pendant in the microwave system.
- Leveraging magnetic resonance images acquired prior to neoadjuvant chemotherapy a soft prior regularization of the microwave imaging can be performed to increase resolution and specificity thus potentially improving the ability of the oncologist to predict chemotherapy effectiveness.
A First Evaluation of the Realistic Supelec-Breast Phantom
Tomas Rydholm, Andreas Fhager, Mikael Persson
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An iterative algorithm is then used to solve the inverse problem and reconstruct a 2-D plane transecting the phantom. The reconstructed images are compared to the ones recovered from a cylindrical phantom of equivalent phantom media. The results show that both phantoms are possible to reconstruct, although the interior of the Supelec phantom is more challenging.
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- We have used our microwave-imaging system in order to successfully reconstruct the Supelec-breast phantom and evaluate its usability.
- Our system is capable of recover images of the studied phantoms, although the interior of the Supelec phantom is challenging due to the high plastic content.
- The studied phantom was developed to be a tool within the microwave-imaging community.
- These are the first published reconstructed images of the Supelec phantom and shows that the phantom is a useful tool when developing a microwave-imaging system.
- It is also shown that our system is capable of reconstructing an image of the phantom without utilizing anya prioriinformation of the phantom, which is unique in the microwave-imaging community.
A Novel Approach for Determining the Electromagnetic Properties of a Colloidal Fluid with Magnetic Nanoparticles for Hyperthermia Applications
Danilo Brizi, Nunzia Fontana, Giulio Giovannetti, Alessandra Flori, Luca Menichetti,Saer Doumett, Giovanni Baldi, Agostino Monorchio,
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In particular, it makes use of indirect equations based on the single order Debye model combined with a punctual set of in vitro SAR measurements. The procedure has a general validity and it can be easily applied in the up-growing field of magnetic hyperthermia studies.
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- A novel approach able to deeply optimize clinical treatments of magnetic hyperthermia with nanoparticles.
- Innovative determination of the complex magnetic permeability of magnetic colloidal fluid by simply using invitro SAR measurements.
- A rapid, alternative and broadband approach for determining the electromagnetic properties of magneticnanoparticles.
- Possibility to test the efficiency of nanoparticles in a tissue-like environment: optimized and realistictreatment planning for magnetic hyperthermia.
Dual-Band Skin-Adhesive Repeater Antenna for Continuous Body Signals Monitoring
Joao Felicio, Carlos A. Fernandes, Jorge R. Costa
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The proposed adhesive repeater is low profile, and it is designed for dual-band operation at the ISM band (2.4 GHz) and in the ultrawideband (UWB) spectrum (4-10.6 GHz) using a single excitation port. The ISM band is used for in-body communication with the implants and the UWB band for off-body burst communication with the BS. The antenna consists of three layers that grant it compactness and performance robustness. We assess the in-body link between the repeater and a custom-designed miniaturized implantable probe antenna. The study is performed in the frequency-domain with results showing adequate input impedance matching (s11 ≤ -10 dB) and robustness to different body parts. We extend the analysis to time-domain by transmitting a synthetized medical signal between the two antennas. In addition, we evaluate the feasibility of an off-body link for burst communication. Again, the results indicate very good performance by the repeater antenna both in terms of impedance matching (s11 ≤ -10 dB) and preservation of time-signals (fidelity ≥ 75%), which is relevant in impulse radio systems. To the authors’ best knowledge, this is the first time this kind of dual-band adhesive antenna is being proposed for BANs, complete with performance tests using frequency- and time-domain figures-of-merit.
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- We assess the viability of having a dual-band skin-attached repeater antenna for in- and off-body communication for the transmission of medical data in the context of Body Area Networks. It is the first time a single-port antenna with both ISM (2.4 GHz) and UWB (4-10.6 GHz) operation bands is proposed for BAN applications.
- The study demonstrates the implementation of a skin-adhesive antenna and the feasibility of both in- and off-body communication links with a passive implant and an external base station, respectively.
- The proposed repeater antenna can be used in continuous monitoring applications, in order to detect health conditions in advance.
- We study for the first time the possibility of having a skin-attached repeater antenna with capability of establishing an in-body communication link with multiple implants and further relay the collected information through a UWB off-body link, thus increasing the off-body communication range and also diminishing the transmission time.
- The present paper includes the complete study of the in- and off-body links not only in the time-domain, in which we transmit a QPSK-modulated ECG signal, but also in the frequency-domain, where we assess the power transfer and link budget.
Monitoring of Patients Suffering from REM Sleep Behavior Disorder
Xiaodong Yang, Syed Aziz Shah, Aifeng Ren, Nan Zhao, Jianxun Zhao, Fangming Hu, Zhiya Zhang, Wei Zhao, Masood Ur Rehman, Akram Alomainy
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There is a high likelihood of the patient being injured or hurt his bed-partner as a result of these enactments. Continuous monitoring of sleeping RBD patients can prevent these harmful events through timely intervention. This work presents a novel method for continuous observation of RBD patients exploiting fine-grained amplitude and phase information of the wireless channel response. The variations in the wireless channel response as a result of different patient movements are assessed and used to identify RBD episodes. The data obtained is classified using support vector machine and delivers accuracy level of more than 90%.To the best of authors’ knowledge, it is a first attempt at using radio frequency signals to sense RBD in real-time.
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- REM Behavior Sleep Disorder is a serious, sometimes dangerous condition that causes people to “act out” their dreams; thus, monitoring and diagnosis of such disease are significant.
- This paper demonstrates the design and implementation of an innovative system for monitoring patients suffering from REM sleep behavior disorder.
- Continuous monitoring of RBD patients is crucial to prevent injury; the proposed identify RBD episodes with accuracy higher than 90%.
- The work leverages the finer-grained information to monitor patients suffering from RBD and fully exploits the amplitude and phase information.
A multi-sensory approach for remote health monitoring of older people
Haobo Li, Aman Shrestha, Hadi Heidari, Julien Le Kernec, Francesco Fioranelli,
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This paper aims to investigate two types of sensing technologies proposed for assisted living: wearable and radar sensors. First, different feature selection methods are validated and compared in terms of accuracy and computational loads. Then, information fusion is applied to enhance activity classification accuracy combining the two sensors. Improvements in classification accuracy of approximately 12% using feature level fusion is achieved with both Support Vector Machine and K Nearest Neighbor classifiers. Decision-level fusion schemes are also investigated, yielding classification accuracy in the order of 97-98%.
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- We propose to combine radar and wearable sensors (accelerometer, gyroscope, and magnetometer) data to simultaneously improve human activities classification rates and minimise false alarms when detecting critical events such as falls.
- Feature selection and fusion methods, at both feature level and decision level, are tested on experimental data collected simultaneously using radar and wearable sensors.
- Sequential forward selection (SFS) significantly helps reduce the dimension of the feature subset and improve the classification accuracy.
- For the feature level fusion, we were able to increase the classification accuracy by 12.2% and 3.3%, compared to the use of radar and wearable sensors on their own.
- Decision level fusion also improves to 94.8% and 96.7% classification accuracy with Fuzzy logic-based decision making and LOGP soft fusion. A novel voting system was also proposed by combining two SVM and KNN classifiers trained by radar and inertial sensor independently. This is demonstrated to achieve 97.8% classification accuracy and 100% fall detection specificity for the ‘fall event’ class.
- Future work will explore the robustness of this multi-sensory approach with additional data collection involving more subjects and more sensors types and configurations.