Accurate Doppler Radar-Based Cardiopulmonary Sensing Using Chest-Wall Acceleration
Mehrdad Nosrati, Negar Tavassolian.
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In this paper, we use the fact that that the displacement signal is a complex Gaussian function rather than a pure sine wave. This function shows a declining amplitude versus frequency; therefore, the heartbeat signal will be much weaker than the respiration signal and can be easily buried in the respiration’s harmonics. However, by exploiting the chest wall acceleration instead of its displacement, the heartbeat signal is greatly amplified, leading to a significantly higher heartbeat rate detection accuracy. Recorded data from 12 healthy human subjects show an average heartbeat rate detection accuracy of more than 95% when compared with reference electrocardiogram (ECG) recordings. The proposed technique is robust, simple, and requires minimum calculation resources which is important for online monitoring and power consumption reduction. Measurement results indicate its potential for being used in reliable non-contact heartbeat rate monitoring systems.
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- This paper presents a new method to increase the robustness and accuracy of Doppler radar-based vital signs monitoring sensors.
- It is shown that using the chest wall acceleration signal yields a better result compared to the chest wall displacement. The heartbeat rate detection accuracy is improved by more than 10% on average.
- A novel mathematical representation for the heartbeat mechanical signal is provided. The model is quite useful in the analysis and understanding of the human heartbeat vibration on the chest wall.
- The new model also confirms our observation that the chest wall acceleration provides a higher detection accuracy than its displacement.
RF Aspects of High and Ultra High Field Magnetic Resonance Imaging [(U)HF-MRI]: Recent Advances
Robert Caverly.
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This paper will show current trends in HF-MRI to mitigate some of these issues and provide a linkage between traditional MRI components and novel structures for UHF-MRI. Transmit and receive structures as well as the use of metamaterials for improved excitation and SNR will be covered. Other examples of these recent trends will be potential antenna structure to replace the current c.oil-based technology, and then finally, receiver/patient protection circuits will be covered.
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- High magnetic field magnetic resonance imaging requires a new look at radio frequency structures for excitation and reception of the imaging signals from nucleons. This paper provides an overview of some of the current work being done for high frequency, high magnetic field magnetic resonance imaging.
- New transmit and receiver structures are utilizing electromagnetic phenomenon rather than simple inductive effects as the frequency increases and wavelength (λ) decreases, allowing the use of metamaterials and wireless technologies.
- These new radio frequency structures will provide enhanced signal to noise ratio, leading to increased contrast and higher resolution images
- Improved, high resolution images will lead to better medical diagnoses.
Development of Water Content Dependent Tissue Dielectric Property Models
Sevde Etoz, Christopher L. Brace.
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However, dehydration effects due to thermal heating have not been fully characterized. We combined 1) Maxwell-Fricke mixture theory with a four-pole Cole-Cole equation to include water and air content dependency and as the second approach a different 2) Maxwell mixture model was coupled with a Debye function. The proposed approaches (1 and 2) were able to predict the permittivity ( ϵ′ ) and conductivity ( σ ) of bovine liver and swine lung tissues at different hydration and inflation states from 1-15 GHz. A second approach coupling Maxwell and Debye models required fewer assumptions and modelled tissue properties with higher accuracy (less than 15% mean percent error in all tissue types). These models may help improve the accuracy of microwave ablation simulation when tissue water content changes as a result of vaporization, and may facilitate personalized treatment planning.
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- Tissue constituents, air and water can be used as inputs to dielectric mixture models to predict dielectric properties of liver and lung at different hydration and inflation states, respectively.
- Maxwell mixture theory is more successful than Maxwell-Fricke mixture theory for tissue dielectric property modelling in both low and high water content tissues.
- Mixture models can be coupled with Debye and Cole-Cole equations to construct wideband tissue dielectric property models that can be used for multiple tissue types that have various water contents as well as different hydration states of the same tissue.
- These models will potentially increase the accuracy of microwave ablation simulations of liver and lung by accounting for changes in tissue constituents due to temperature elevation and water vaporization.
Non-Contact Human Gait Analysis and Limb Joint Tracking Using Doppler Radar
Farhan Quaiyum, Nghia Tran, Jean E. Piou, Ozlem Kilic, Aly Fathy.
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Here, we investigate the feasibility of extending the 1-D block processing algorithm to distinctly track specific limb joints and discuss the advantages and limitations of the technique for CW radar. To establish a repeatable reference data, we run a full wave EM analysis on customized Boulic human model emulating specific video recorded body motions. Results based on measured data are in agreement with simulated ones for simple motions like swinging one hand or one leg only. The proposed technique is also successful in extracting lower body parts while the whole body is in motion, however it is still hard to clearly extract upper body parts like swinging hands.
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- The developed EM model for human motions creates repeatable and realistic reference data which when coupled with the signal processing technique can be useful for obtaining a full understanding of human limb joint motion analysis.
- The proposed method is successful in extracting different limb joint trajectories from a complex human motion but with some limitations such as difficulty in tracking hands for a walking subject and reliance on reference data to identify the desired motion details.
- The targeted applications of this work are treating patients with joint problems, athlete performance analysis, motion classification, and so on.
- The significance of this work is the development of a limb joint tracking technique suitable for use with low cost and simple Doppler radar in a typical non-controlled environment.
- A by-product of this work is the use of a portable and flexible software-defined transceiver system as the Doppler radar utilized in the experiments.
Mesoporous titania-coated biosensor and FEM model design for highly sensitive detection of low molecular weight targets
Ollivier Tamarin, Hamida Hallil Abbas, Wassim Ouelhazi, Maxence Rube,Jean Luc Lachaud, Vincent Raimbault, Cedric Boissiere, Marie Paule Bonnet,Dominique Rebiere & Corinne Dejous.
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The strategy of using such Love wave devices, with 3D porous layers, offering further easy functionalization, aims not only to increase the amount of targets caught on the sensor surface, but also to enhance the detection mechanism by a higher perturbation of the Love wave acoustic energy which could be trapped inside the 3D sensitive layer. First, as a proof of concept, experimental devices with a 3D titania mesoporous layer were realized, and they have shown a good agreement with simulated results. Furthermore, experimental test with several Newtonian liquids are investigated, in a range of viscosities from 1 to 7 cP, typical of those concerned by our biochemical applications. The sensitivity with a 300 nm thick porous sensing layer was 10 times that of the bare device, with interesting dynamical issues to be further studied, giving rise to the great potentialities for biological detection of low weight biochemical targets.
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- We present an easy-to-use, portable, autonomous RF electronic readout circuit as a first proof-of-concept for a passive biosensor network platform that integrates passive acoustic wave biosensors and their remote interrogation.
- The acoustic device can detect low-weight biochemical targets in low-volume samples and represents an important step toward a biosensor network platform for cancer diagnosis and monitoring of environmental health.
- The association of a Love wave device with functionalized porous matrices could improve the performance of the sensor in biological media for highly sensitive detection of low weight molecular targets while facilitating the development of an easily regenerable system.
- The main innovation is related to the modelling of the device and simulation using the Finite Element Method (FEM), which is a good way to take into account the physical properties of porous 3D-layers which would also make it possible to design very sensitive layers adapted to the detection targets, such as cancer bio-markers and toxins.
- This novel approach has potential applications low molecular weight biochemical detection for early cancer diagnosis and environmental monitoring, among others.
Combined Effect of 60 Hz Magnetic Fields and Anticancer Drugs on Human Hepatoma HepG2 Cells
Makiko Kakikawa, Tetsuya Maeda, Sotoshi Yamada.
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However, since the prokaryotic bacterial cells, E.coli, differ from human cells which are eukaryotes and multicellular organisms in many ways, it was not clear whether the magnetic fields affect a potency of anticancer drug against human cancer cells. In this study, we designed and produced magnetic fields exposure device for human cancer cells in culture, and investigated whether 60 Hz, 50 mT magnetic fields affect the potency of anticancer drugs against human hepatoma HepG2 cells. The results of experiments with an anticancer drug, cisplatin indicated that the quantity of viable HepG2 cells become decreased significantly by the combination of cisplatin and magnetic fields as compared to that by cisplatin alone. This suggested that 60 Hz, 50 mT magnetic fields increase the cytocidal activity of cisplatin to human hepatoma cells. The efficiency of the anticancer drugs, mitomycin C and doxorubicin against HepG2 cells was also increased significantly by exposure to magnetic fields, although the time associated with the greatest enhancement of the drugs potency achieved by magnetic fields differed among drugs. These results suggest that 60 Hz, 50 mT magnetic fields strengthen the effect of anticancer drugs on human cancer HepG2 cells.
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- The magnetic fields exposure device was newly designed and produced for generating magnetic fields in a CO2-incubator culturing of human cells.
- The results suggested that 60 Hz, 50 mT magnetic fields enhance the efficacy of anticancer drug to human cancer cells.
- Three types of anticancer drugs used in this study are affected differently by the magnetic fields. The magnetic fields increase the effects for all the drugs, by which the numbers of viable cells are decreased by 40% than those with only the drugs alones.
- If our finding can be applied clinically, magnetic fields exposure to cancer site might allow for an effective target chemotherapy, reducing dosage and suppressing side effects.