Non-Contact Human Gait Analysis and Limb Joint Tracking Using Doppler Radar
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Here, we investigate the feasibility of extending the 1-D block processing algorithm to distinctly track specific limb joints and discuss the advantages and limitations of the technique for CW radar. To establish a repeatable reference data, we run a full wave EM analysis on customized Boulic human model emulating specific video recorded body motions. Results based on measured data are in agreement with simulated ones for simple motions like swinging one hand or one leg only. The proposed technique is also successful in extracting lower body parts while the whole body is in motion, however it is still hard to clearly extract upper body parts like swinging hands.
Mesoporous titania-coated biosensor and FEM model design for highly sensitive detection of low molecular weight targets
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The strategy of using such Love wave devices, with 3D porous layers, offering further easy functionalization, aims not only to increase the amount of targets caught on the sensor surface, but also to enhance the detection mechanism by a higher perturbation of the Love wave acoustic energy which could be trapped inside the 3D sensitive layer. First, as a proof of concept, experimental devices with a 3D titania mesoporous layer were realized, and they have shown a good agreement with simulated results. Furthermore, experimental test with several Newtonian liquids are investigated, in a range of viscosities from 1 to 7 cP, typical of those concerned by our biochemical applications. The sensitivity with a 300 nm thick porous sensing layer was 10 times that of the bare device, with interesting dynamical issues to be further studied, giving rise to the great potentialities for biological detection of low weight biochemical targets.
Combined Effect of 60 Hz Magnetic Fields and Anticancer Drugs on Human Hepatoma HepG2 Cells
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However, since the prokaryotic bacterial cells, E.coli, differ from human cells which are eukaryotes and multicellular organisms in many ways, it was not clear whether the magnetic fields affect a potency of anticancer drug against human cancer cells. In this study, we designed and produced magnetic fields exposure device for human cancer cells in culture, and investigated whether 60 Hz, 50 mT magnetic fields affect the potency of anticancer drugs against human hepatoma HepG2 cells. The results of experiments with an anticancer drug, cisplatin indicated that the quantity of viable HepG2 cells become decreased significantly by the combination of cisplatin and magnetic fields as compared to that by cisplatin alone. This suggested that 60 Hz, 50 mT magnetic fields increase the cytocidal activity of cisplatin to human hepatoma cells. The efficiency of the anticancer drugs, mitomycin C and doxorubicin against HepG2 cells was also increased significantly by exposure to magnetic fields, although the time associated with the greatest enhancement of the drugs potency achieved by magnetic fields differed among drugs. These results suggest that 60 Hz, 50 mT magnetic fields strengthen the effect of anticancer drugs on human cancer HepG2 cells.
Application of Two-Dimensional Discrete Dipole Approximation in Simulating Electric Field of a Microwave Breast Imaging System
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We have modeled the field distributions in COMSOL Multiphysics as baseline results to benchmark the DDA simulations. We have also investigated the adequate sampling size and the effect of inclusion size and property contrast on solution accuracy. In this way, we can utilize the 2D DDA as an alternative, fast and reliable forward solver for microwave tomography. From a mathematical perspective, the derivation of the 2D DDA and its application to microwave imaging is new and not previously implemented. The simulation results and the measurements show that the 2D DDA is a well-grounded forward solver for the specified microwave breast imaging system.
Miniaturized Broadband Microwave Permittivity Sensing for Biomedical Applications
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Circuits designed can act as the basic building block for a wide span of biomedical applications, ranging from wearables to permittivity imaging. Experimental results of manufactured prototypes demonstrate measurement noise reduction through bridge balancing, debye model parameter estimation of independent material with a 1.6% error using full frequency dataset and 5.3% in high energy efficiency mode, as well as image construction based on material permittivity differences.
A Versatile Magnetic Exposure System for In-Vitro, Ex-Vivo and In-Vivo Experiments Finalized to Therapeutic Applications in the IF Range
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Laboratory experiments aimed at defining in vitro and in vivo outcomes are required, and reliable low intensity magnetic field exposure systems are needed. In the present study, we have performed the analytical and numerical design of a novel magnetic exposure system suitable for different biological applications, such as magnetoliposome drug delivery, ex vivo experiments on brain slices and in vivo studies. This system is be able to generate intensities of the order of mT in a frequency range from ELF to 20 kHz.
